Every use case reduces to a mismatch between where the person lives and where their mail should arrive. The mismatches are boring and universal.
A business address that is not the home
Registering an LLC, a sole proprietorship, or a domain does not require a home address on public records if the operator does not want it there. USPS itself markets the PO Box for “a side hustle or a storefront”. Business correspondence, invoices, tax notices and vendor checks all sit in the box; suppliers who want a physical street format go through Street Addressing.
Rental building or shared mail
Apartments with a single lobby mail slot, rooming houses, and shared driveways lose mail routinely. Sensitive envelopes — tax documents, credit-card offers, replacement cards — land safely in a box with a lock and a key, and the household knows what came without asking.
Package security
Porch theft is the plain reason. Even where insurance covers a loss, replacing an item and refiling a claim is a day nobody wants. Packages arrive at the Post Office and wait behind the counter or in the box until the owner walks in.
Moves and travel
An address that does not change when the lease does. Anyone moving between apartments in the same town, traveling for months, or between houses can hold the same PO Box across the interval; the driver's license and the bank keep working.
Temporary time away
A hold on residential mail lasts 30 days at most. A PO Box holds everything indefinitely while the traveler is away; the box does not care whether it is filled today or in six weeks, and the neighborhood mail person is not accumulating a suspicious pile at the front door.
Street Addressing for carriers other than USPS
The Street Addressing service lets a PO Box holder use the Post Office's street address followed by their PMB (Private Mailbox Number) style suffix, and UPS, FedEx and Amazon can then deliver packages to the Post Office where staff place them in the box. Not every Post Office offers it — call before signing the lease.